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Phenotypic changes in brain and behavior of genetically modified mice can be masked or exacerbated by the genetic background of the mouse strains used.
Three factors need to be considered when comparing experimental results from studies in mice and humans: In addition to species-specific differences, phenotypes are affected by the genetic background of the mouse strain being analyzed, and by microbial factors.
Overall, these results suggest that PVL induction of host immune responses depends on the genetic background of the mouse.
It is possible the difference in the genetic background of the mouse strain may have also influenced the results.
In a previous study, Freeman et al. reported that tumorigenesis in Pten heterozygotes was strongly affected by the genetic background of the mouse [36].
This confirms that the genetic background of the mouse strain plays a role in the development of different immunologically linked cell subtypes and probably also in their cytokine production.
Similar(41)
Variable behavioral phenotypes were observed depending on the line and genetic background of the mice.
First, the genetic background of the mice could play a role.
Thus, 96% of the genetic background of the mice used in the present study comes from the 129 strain.
In these mouse models, no causal connection has been made between the genetic background of the mice and NOTCH activation.
Among the factors affecting the latency and the spectrum of tumors induced by γ−irradiation are the irradiation dose and the genetic background of the mice (genetic background of mouse strain as well as presence of defined genetic mutations).
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background of the image
context of the mouse
background of the ex-offender
background of the project
background of the pulse
background of the app
background of the paper
background of the problem
background of the program
background of the background
background of the drama
background of the motivation
background of the discussion
background of the texture
background of the student
background of the Program
background of the analysis
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