We are also uncertain about the biological background for the loss of gene sets C and E from the mt genomes of the ancestral euglenozoan (fig. 4 B).
In that study, the unc-40 point mutation, unc-40 ur304), unc-40 ur304t to disrupt axon protrusion unless in the background of the loss-of-function unc-6(ev400) mutation or the unc-6(rh46) mutation.
"With the background of that loss, I realized we were getting older and there is no guarantee how long either of us might have".
Our findings implicate Rag activity as an important contributing factor affecting lymphoma development in a p73-null background, while the loss of apoptosis through p53- and p73-deficiency allows accumulation of such genetic alterations.
Tc1 animals cannot be kept on a pure genetic background due to the loss of transmission of the Hsa21 [38].
Written over a decade on three typewriters (Bengis does not own a computer), "Metro Stop Dostoevsky" is about a friendship between a woman very much like Bengis and a Russian woman referred to only as B. A cast of ghostlike characters flickers in the background, aching for the loss of things past -- stable jobs, affordable food, the time they used to have for friendships.
Vhl null cells nonetheless exhibit a lower proliferation rate than Vhl wild-type cells, even in the background of loss of the p53 and pRB cell cycle checkpoints, implying that there may be additional cellular responses that represent barriers that prevent full transformation of Vhl/Trp53 mutant cells.
Two different genotypes were used as controls in this study to reduce genetic background differences between the loss-of-function and overexpression comparisons.
Although taz −/− embryos develop normal RPE cells, compromising Taz function on a yap −/− background enhanced the loss of RPE cell phenotype as compared with yap −/− mutants alone.
Currently, no method exists for automatically processing next-generation sequencing DamID (DamID-seq) data, and the use of DamID-seq datasets with normalization based on read-counts alone can lead to high background and the loss of bound signal.
Background selection (the loss of non-deleterious variants due to selection against linked deleterious alleles) may further reduce linked genetic diversity in this selfing species (Rockman et al., 2010).
