Revival of natural product discovery will require high-throughput identification of novel compounds within a large background of known substances.
To asses the suitability of this bioisosteric similarity for virtual screening, we compared the recovery of known drugs against the background of other substances.
Additionally, demographic features such as age, gender, ethnicity, educational background, insurance coverage, polypharmacy, and history of substance abuse should also be taken into account when considering treatment with LAIs [ 40, 42- 48].
Yet there's a shadow movie looming alongside these fictional films — of directors themselves stepping outside of character to speak their own thoughts, in their own names — and that virtual movie is the one that's realized in interviews, in directors discussing, in print or onscreen, the substance and background of their art.
I feel that once again, we see that we are putting people in authority who have no training of substance, nor with the appropriate background.
They'd rather have a governor who is wrong on all issues of substance but has not misrepresented his background.
Standardized clinical interviews (SWEDATE) and hospital records contained background data and mandatory information on length and intensity of substance abuse by mode of administration [ 24].
10 P.M. (13) GIRL TROUBLE -- Their names are Shangra, Stephanie and Sheila, and they come from backgrounds of poverty and substance abuse.
Interviews with friends, relatives and co-workers fill in this remarkable woman's background: an ex-alcoholic herself, she lost two sons and a husband to consequences of substance abuse.
Two effects of these background factors on substance use levels can be discerned.
