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10 This again implies that the background of mice used previously possessed a non-B6 component.
Strain background of mice used at SUMC was ∼85% C57BL/6J and ∼15% 129SvEv.
It remains to be determined whether the differences in trabecular bone response to IGF-I gene disruption is due to genetic background of mice used in different studies.
Whether this discrepancy is explained by the mixed genetic background of mice used in the former study or other factors remains to be determined.
However, no mention of backcrossing to a pure background strain was indicated, and hence, the precise background of mice used in the final analysis remains unclear.
This contradictory observation could be due to different background of mice used in these two studies or different initial expressing level of Foxp3 in T cells [ 75].
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The background strain of mice used for many studies of the human SOD1 mutation is a B6SJL mixed hybrid strain [B6SJL-TgN SOD1-G93A 1GUR] maintained by crossing transgene-positive male mice with B6SJL F1 hybrid females.
Previously described [ 36] RNAseq data were chosen to match the genetic background and approximate age of mice used in our experiments.
The majority of mice used in this study were transgenic strains with mixed genetic backgrounds.
Thus, 96% of the genetic background of the mice used in the present study comes from the 129 strain.
Which C3H genetic factors actually contribute to this arthritis pathway remain to be determined, and this needs a careful and cautious analysis of the precise genetic background of any mice used.
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