Sentence examples for background of mice generated from inspiring English sources

This strategy obviated the necessity of extensive backcrossing, which would have been required for converting the genetic background of mice generated by targeting the ES cells from 129 mouse strain.

Although the genetic background of the LKB1-deleted mice generated here (FVB/129S6/C57BL6) and in earlier studies (16, 18) differs slightly from that of those deleted for AMPK (C57BL6) (46), it seems unlikely to us that this difference could explain the markedly different phenotypes of mice deleted for LKB1 vs. AMPK in the β-cell.

These mice were back-crossed more than six times with C57BL/6 strain before experiments were done to make sure that the majority (>98%) of the genetic background of generated mice was of C57BL/6 origin.

These mice were backcrossed >6 times with the C57BL/6 strain before experiments were done to make sure that the majority (>98%) of the genetic background of generated mice was of C57BL/6 origin.

Some of these knockout mice, generated in the 129 strain and backcrossed to the B6 background strain, carry regions of the 129 genome surrounding the knockout locus.

Two sublines breed Adar1 −/+ in the Ifnar1 −/− background, and crosses of these mice generate Adar1 −/− ; Ifnar1 −/− embryos.

Fus1 KO mice generated by Dr. A Ivanova were backcrossed to 129sv background in the laboratory of Dr. S Anderson (NCI-Frederick).

We next mated HMGB1-Tg mice with Atxn1-154Q knock-in mice (Atxn1-KI mice) of the same background C57BL/6 and generated double-transgenic mice Atxn1-KI HMGB11 mice).

To clarify these issues, we used SOD1H46R mice, which exhibit a widespread axonal degeneration with slowly progressive motor neuron degeneration in the spinal cord [31] instead of SOD1G93A mice, and generated SOD1H46R mice on an Als2-null background.

C57BL/6 background NOD2 KO mice were generated in the laboratory of M. Giovannini (Barreau et al, in preparation).

The background of Tsc1flox/flox mice is 129S4/SvJae, and these mice were backcrossed to mice with a C57BL/6 background for eight generations before use.