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Longnecker (2006) raised the possibility that pharmacokinetic variability may explain the associations observed between organochlorines and diabetes at background levels of exposure.
The use of these chemicals is presently banned or restricted; but because of the chemicals' persistence in the environment, adverse health outcomes related to background levels of exposure are still a concern for the general population (World Health Organization 2010).
In this study, we analyzed NHANES data from 2007 2008 to estimate associations of Pb, Hg, and Cd with TH levels in a large U.S. population with background levels of exposure.
These analyses included the same number of participants for each outcome as corresponding models of associations with cumulative PFOA exposure including estimated background levels of exposure (approximately 4 ng/mL serum).
Differences in the toxicities of particular congener mixtures may contribute to inconsistent results and make comparisons between studies difficult [ 15], particularly in conjunction with different background levels of exposure.
Olsen et al. (2007) studied 140 Red Cross donors in 2000 and 2005 with background levels of exposure and found that men had significantly higher serum levels of PFOA than did women but that there were no trends with age.
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Our results also suggest that PCBs affect TH homeostasis even at the low background level of exposure found in the CHAMACOS population.
The occupational exposure to PBDEs in children working at a waste disposal site, and a substantial background level of exposure to PBDEs in the urban population, are clearly shown.
Findings also suggest that PCBs affect TH homeostasis even at the low background level of exposure found in the CHAMA-COS (Center for the Health Assessment of Mothers and Children of Salinas) population.
To optimize the use of this model, the authors recommend that efforts to monitor toxics include regular data collection, including total diet data to estimate background levels of ongoing exposure, in young adult populations.
For the purposes of our analysis, women with only background levels of occupational PCB exposure at the time of conception were considered unexposed; these women may have worked in an area of the plant where no PCBs were ever used prior to conceiving the child, or may not have worked in the plant until after the conception.
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