Exact(2)
If, on the other hand, background intakes are high compared with current body concentrations, the estimated apparent elimination rate will be lower than the intrinsic rates.
Doubling the estimated intakes resulted in another 10 20% decrease in estimated half-lives, whereas halving the estimated intakes pushed the half-life estimates closer to the mass-based apparent half-lives calculated without considering background intakes (data not shown).
Similar(58)
The average background intake of the Reassessment was 61.0 pg TEQ/day, and using more current data, the average background intake was 40.6 pg TEQ/day.
The US Environmental Protection Agency's 2004 Dioxin Reassessment included a characterization of background exposures to dioxin-like compounds, including an estimate of an average background intake dose and an average background body burden.
Estimation of plausible background intake rates.
Meal frequencies were chosen to limit DLC intake to 20% above the background intake.
We investigated the impact of alternative assumptions regarding these background intake rates.
First, background intake and body weight are generally assumed to be proportional in adults (i.e., intake is expressed in units of nanograms per kilogram of body weight per day).
Under this assumption, a one-compartment model parameterized for average adults, as presented in Equation 2, is equivalent to a one-compartment model parameterized with age-dependent body weight and background intake proportional to body weight [see Supplemental Material (doi 10.1289/ehp.0900648.S1)].
As a consequence, background intake is a possible confounding factor in estimates of the human elimination half-life from LD when complete isolation from ongoing exposure is not feasible (Shirai and Kissel 1996).
If the concentrations in the present study are closer to those consistent with steady state with current background intake rates, the apparent half-life of elimination will be longer (Bartell 2012; van der Molen et al. 1998).
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