This value was based on the patients' background in a trial of orally administered spherical carbon adsorbent AST-120 [ 40].
Greater attention needs to be given to gene profiles and the impact of genetic lesions in malignant epithelial cells and in the stromal background in clinical trial design and during the selection of patients for therapy.
As someone with a background in clinical trials, this symposium was as relieving as a soak in a nice, warm bath.
As visualised by Hussain-Gambles et al. [ 36], a major problem is that researchers tend to exclude people with different cultural, linguistic, ethnic or national backgrounds in clinical trials.
There are several reasons for this variability, including differences between BCG substrains, exposure to non-tuberculous mycobacteria (NTMs), the nutritional or genetic background of the population, differences in trial methods and variations between different clinical Mycobacterium tuberculosis strains [ 2- 6].
Isabelle Rothe, Jenapharm's chief executive, said she could give only some general background in advance of the trial, but she said she had "sympathy" with the victims of the doping scandal, and admitted that many of them were "under age" when they were given the steroids.
Background: In a previous clinical trial comparing COMVAX™ with its monovalent components, PedvaxHIB™ and RECOMBIVAX HB™, one of 92 comparisons of post-vaccination adverse experiences revealed a higher rate of unusual, high-pitched crying following the second, but not the first or third doses of COMVAX™ compared with two monovalent control vaccines.
Assumptions about the willingness of women from minority backgrounds to participate in trials has also led to an under-representation of these women in research generally and in clinical trials [ 53, 54].
The Rodney King trials run in the background, in the form of a TV churning through the images that led to the riots.
In the background of the trial were two other important men, William Bulger, Whitey Bulger's younger brother and the longtime president of the Massachusetts Senate, and Robert S. Mueller III, the director of the F.B.I.
