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The morphological top-hat transform is used to enhance ROI images, with the aim of detecting objects that differ in brightness from the surrounding background; in our case, it was used to increase the contrast between the MCs and the background.
Similarly, impact of genetic background (in our case C57BL/6 mice were used) remains unclear.
The parental fibroblasts used for AD-iPSC generation in this study did not carry any mutations in Alzheimer-related genes which excluded the possibility to use the same genetic background in our case.
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Each article, called a page, is separated into its title and body and stored in a single table in the background RDB (in our case, mySQL).
Rather, this difference is most likely due to the difference in genetic background, which in our case is an equal mixture of C57Bl/6 and Sv/129 but a pure C57Bl/6J through backcrossing in the prior study.
[ 28] The simple comparison of background characteristics in our case study shows that, aside from gender, the researcher could definitely be considered an 'outsider' but this need not be detrimental to the research and it was felt that the differences between all three parties may have been beneficial.
This tool detects overrepresented functional gene categories in the gene list compared with a background genome, which in our case was the set of genes present on the filtered array.
Contamination can also be a problem in MS, causing identification of irrelevant "background" proteins as seen in our case.
In our case, the background of the estimated foreground is uniform.
In our case, the background is the overall genomic codon usage.
Taking the background characteristics of all three parties in our case study (Table 1), there are clear differences but also some similarities.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com