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The Edardl-J mice (FVB background) have been bred at the PBES of IFR 128 (Lyon).
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First, the genetic background difference may lead to the phenotypic difference: whereas our Bmpr1a flox/flox and Pdx1-Cre mice have been bred on the C57BL/6 background for over 10 generations, the Pdx1-dnBmpr1a mice are generated on a mixture of C57BL/6 and CBA genetic backgrounds (Goulley et al., 2007).
They have been bred onto the C57BL/6J background until congenic [ 9].
Haemophilia B mice with targeted deletion of murine F9 ('null mutation') have been bred on BALB/c and C3H/HeJ backgrounds for >10 generations [ 20].
The targeted Pax3 lines used in this analysis have been bred for many generations on a C57 BL6/DBA2 genetic background.
Mice used in these experiments have been bred for at least five generations onto the C57/BL6 background.
They have been bred not to kill.
GM cows with resistance to BSE have been bred.
Within the breed, lines with different body sizes and proportions have been bred.
Haemophilia B mice with targeted deletion of murine F9 ('Null mutation') had been bred on C3H/HeJ background for >10 generations (Mingozzi et al, 2003).
In marked contrast, USP18 null mice in this study had been bred onto the FVB/N strain background and rarely exhibited neurological symptoms.
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