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In this case, novel discoveries emerged against background expectations shaped by the guiding analogy.
Indeed, because we used the set of conserved elements from which the HARs, CARs, and MARs were identified as the baseline in our tests for enrichment, the observed patterns of fast-evolving regulatory elements nearby genes involved in areal patterning reflect a true enrichment above background expectations that is not biased by the larger number of CNSs nearby certain classes of genes [36].
It provides background expectations about population genetic variation, increasing our understanding about the population frequency of disease-causing alleles, facilitating the estimation of recombination rates from patterns of linkage disequilibrium, and allowing robust identification of regions of the genome targeted by natural selection [2], [13], [14].
with background expectations for that statistic generated from genome-wide data, which should reflect neutrality.
The baseline questionnaire included questions about sociodemographic background, expectations and attitudes to antenatal education, childbirth and early parenthood.
One particular focus of our ongoing and future research efforts will be the derivation of theoretically well-founded background expectations of subgraph counts used in Netdis.
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This estimated expected count serves as our background expectation.
After vetoing, the remaining rate of accepted muon-induced neutrons in the EDELWEISS-II dark matter search was determined to be Γμ nirred<6⋅10−4evts/ kgd) at 90% C.L. Based on these results, the muon-induced background expectation for an anticipated exposure of 3000 kg d for EDELWEISS-III is Nμ n3000kgd<0.6 events.
Thus, it appears that relative to background expectation, a decrease in expression appears to be more common and of a greater magnitude than an increase in expression in gene families.
The model takes account of four factors, (1) the background expectation of accumulating additional errors, (2) the background and (3) increment in the probability of dying (based on the level of cognitive deficit) and (4) the increment in the expectation of incurring more or fewer errors, again based on the level of baseline cognitive deficits.
The importance of the background expectation in Netdis becomes apparent when the tree is generated using Netdis_ ne instead (Supplementary Fig. S6a).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com