Qi, Q. et al. Diversity and clonal selection in the human T-cell repertoire.
Baranzini, S. E. et al. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions.
Phylogroup 1 treponemes had the highest levels of OTU richness (diversity) and clonal abundance within both subject groups.
I fully believe in diversity - diversity of thought, diversity of background, diversity of cultures and mindsets.
In Figure 6, values of D2and D3are shown for varying levels of background selection and clonal interference.
We can distinguish between the effects of background selection and clonal interference by using a third statistic, D3.
In the right panel, a high mutation rate increases levels of both background selection and clonal interference.
This may be especially relevant in PBMC-based repertoire analyses where it remains to be seen whether the clonal expansion signature is dominant enough to show through the background diversity of other cell populations.
The dynamics are complex and with highly variable patterns of genetic diversity and resultant clonal architecture [ 1].
The extent of background selection, hitch-hiking and clonal interference can be evaluated using the diagnostic statistics presented here.
