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Furthermore, with the genetic background difference [26], [33] [35] and the different environmental factors, such as eating habits, lifestyle, geographical localities and climate between the Northern and the Southern Han Chinese population, the results of these 2 studies might also be different.
These probes had the highest median difference in beta value at 0.11 for Infinium I and 0.13 for Infinium II, both of which were significantly different to the expected background difference (p < 0.001) when compared to WGBS.
However, the median difference in beta value of these probes (0.07 Infinium I, 0.10 Infinium II, Figure 1c, d, Table 2 category Indels) was not different from the expected background difference and the correlation was similar to the high-quality probes (Table 2 category High quality).
This was likely to be caused by background difference between indica and japonica.
(c) Background difference detection image by no.1 sub-eye camera using Roberts operator.
(a) Background difference detection image by no.1 sub-eye camera using lateral inhibition method.
Similar(20)
In order to rule out individual background differences across different origin groups, individual-level variables have to be taken into account.
This also eliminates the problems with strain background differences as mouse lines obtained from different laboratories might be maintained on different mouse backgrounds.
This served to reduce the chance of identifying genes which showed different transcript abundance due to genetic background differences.
Two different genotypes were used as controls in this study to reduce genetic background differences between the loss-of-function and overexpression comparisons.
It is well known that genetic background differences in inbred mice affect their behavioral traits.
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