Sentence examples for background did not alter from inspiring English sources

Whereas deletion of N-WASP on a wild type background did not alter T cell development, deletion of both WASP and N-WASP severely compromised T cell development, producing a phenotype similar to that of waspΔVCA mice, i.e., marked thymic hypocellularity and reduced number of peripheral T cells with blockage at the level of DN3 thymocytes [35].

We then ensured by a comprehensive set of biochemical experiments that the same mutations in the wild type background did not alter essential activities of Ras, such as GTP-loading, GTP-hydrolysis or effector binding, which classically increase Ras activity.

As observed on a wild-type background, endothelial-specific overexpression of Nox2 on a hyperlipademic ApoE−/− background did not alter body weight, basal systolic blood pressure, or pulse rate at either 9 or 24 weeks of age (Supplementary material online, Table S1 ).

Another interesting feature is that RYE overexpression in a wild type genetic background does not alter sleep, which is inconsistent with a factor that directly drives the S process (this should elevate or phase advance sleep).

In wild type and mutant background, CaZF did not alter steady state low expression level of ENA1 transcript in control condition.

We confirmed that in the WT background, ectopic reelin did not alter cortical layering (Fig. 3A,B,E).

In the presence of the endogenous protein (WT or heterozygous backgrounds) ectopic reelin did not alter ApoER2 expression.

Furthermore, these improvements are not likely explained by increases in the dose of background antihyperglycaemic therapies, as most patients did not alter their background dose.

In the pad4-1, npr1-1, and NahG background, the ocp3-1 mutation did not alter the level of susceptibility to Pst DC3000.

While transfection with RSV F did not alter background SBA staining, cells transfected with RSV G showed a marked increase in SBA staining relative to untransfected control cells, due to the heavy glycosylation of the RSV G protein.

Surprisingly, we found that inhibition of Hsp90 caused the partial restoration of the trabeculae in the severe genetic background (Fig. 2) but did not alter the craniofacial phenotype of mild mutants (data not shown).