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ApoE−/− male mice on a C57BL6/J background and wild type C57BL6/J male mice were from the Harlan Nossan (Udine, Italy).
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GluR5−/− mice were maintained on a mixed 129Sv x C57BL/6 background and wild-type littermates were used as controls.
APP/PS1 transgenic mice of C57BL/6J background and wild-type littermates, were purchased from the Chinese Academy of Medical Science.
For all animal experiments 8 12 week old homozygous IL-10 gene-deficient mice (IL-10−/−), generated on a 129 Sv/Ev background and wild-type 129 Sv/Ev controls were used.
Mice lacking RAG2 on a C57BL/6 background and wild-type controls were from Taconic (Hudson, NY).
All yeast experiments used a prototrophic diploid strain (DBY12007) with a S288c background and wild-type HAP1 alleles (Slavov and Botstein, 2011).
TNFR1−/− female mice in a C57/BL6 background and wild-type littermates were obtained from the University of Campinas Breeding Centre CEMIBB).
Eight-week-old male AnxA1 knockout (AnxA1 KO) mice on a C57BL/6 background and wild-type (WT) animals were purchased from Charles River Laboratories (Charles River UK Ltd., Margate, UK) and fed for 4 or 8 weeks with either MCD or control diets (Laboratorio Dottori Piccioni, Gessate, Italy).
Smad7 fl/fl, CD4-Cre (Lee et al., 2001) and CD2-Smad7 (Dominitzki et al., 2007), all on C57BL/6 background, and wild-type C57BL/6 mice (Charles River) were kept in a specific pathogen-free barrier at the central animal facilities of the Universities of Mainz and Regensburg.
The C7-hypomorphic mice (Fritsch et al, 2008) on mixed C57BL/6 129sv background and wild-type littermates were kept in a pathogen-free facility at the University of Freiburg and given food and water ad libitum; C7-hypomorphic mice also had access to a special soft-food diet (Fritsch et al, 2008).
The ort6 flies have Oregon-R background [32] and wild type eye pigmentation.
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