A polyol (tripentaerythritol-electron rich component), which acts as an electron donor to the polymer backbone, was added to enhance the conductivity.
Additional "backbone" interrogating clones along each chromosome were added to aid in the detection of chromosome imbalance outside of targeted regions.
61 After all backbone segments and side chain conformations had been chosen for an intermediate model, hydrogen atoms were added to complete the valence requirements.
Following iterative backbone annealing based on the structure of Hif1an (PDB entry 1h2k), 2OG and Fe(II) were added to the 3D model of Jmjd6.
Twenty-five Na+ ions were added to the system for neutralization of the charge on the sugar-phosphate backbone.
Recently, backbone flexibility was added to the docking algorithm which led to improved predictions, including lower rmsds among top scoring ligands (63).
An enhanced force constant for backbone-connections (bb-cons) is added to reflect the chemical reality (also used in Hinsen's ENM and BENM, see below) hence the name Chemical Network Model (Kondrashov et al. 2006).
This particular test is not relevant for the bistochastic filter, since it does not consider local edge weight distributions when choosing which edges are added to the backbone network.
Specialty modules, including ICU, can be added to this backbone depending on mission requirements.
Interestingly, all randomized trials with one of the somewhat less intensive chemotherapy backbones (i.e. IFL bolus regimen, 5FU/LV bolus regimens; capecitabine) showed consistently an impressive improvement of PFS (HR 0,54; 0,50 and 0,63 respectively) when bevacizumab was added to that backbone [ 10, 12, 19].
