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The backbone therapy in all these series is CHOP-based chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone).
A total of 30%% of the tofacitinib-treated patients achieved an ACR50 response compared to 10%% of patients receiving placebo, irrespective of backbone therapy.
As previously reported at week 48 [13], the mean change from baseline in creatinine did not appear to be driven by NRTI backbone therapy.
This study prospectively evaluated changes in cardiovascular biomarkers in an underrepresented, racially diverse, HIV-1-infected population receiving abacavir/lamivudine as backbone therapy.
We hypothesised that liraglutide added to metformin backbone therapy in patients with CAD and newly diagnosed T2DM will improve β-cell function and left ventricular systolic function during dobutamine stress.
Liraglutide is, however, expected to induce significant weight loss, which could confound the effect of the backbone therapy in the group that is treated with liraglutide in the first period.
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The backbone therapies varied according to clinical practice.
Also natural surfactant constitutes a backbone of therapy of respiratory distress of the preterm infant; its impact on the pulmonary outcome gets only visible in the meta-analysis when the parameter BPD is combined with death before discharge [68].
30 The backbone of therapy is R-CHOP.
The backbone of therapy has not changed for many years, comprising a combination of an anthracycline and cytosine arabinoside, with dose recommendations that may depend upon patient age.
7 The use of orally administered drugs, which are the backbone of therapy for onychomycosis, is limited by the risk of hepatotoxicity and possible drug drug interactions with other systemic medications.
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