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Eiben, C. et al. Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.
Correia, B.E. et al. Computational protein design using flexible backbone remodeling and resurfacing: case studies in structure-based antigen design.
Backbone grafting of linear motifs is a general method to transplant functional motifs when backbone remodeling of the target scaffold is necessary.
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These results indicate that flexible-backbone remodeling and resurfacing are useful tools for antigen optimization and protein engineering generally.
In flexible-backbone remodeling, an existing backbone segment is replaced by a de novo designed segment of prespecified length and secondary structure.
Previously, an approach to loop remodeling where protein backbone movement is directed by side-chain rotamers predicted to form interactions previously observed in native complexes (termed "motifs") was described.
Remodeling of the DNA backbone promotes nucleotide flipping of the lesion and the complementary base into the solvent and toward the protein surface, respectively.
Other regions of the aptamer make extensive interactions with the large lobe of the kinase domain, remodeling basic regions of the protein so that they can better interact with the polyanionic phosphodiester backbone of the RNA.
She is considering remodeling.
James, A. Airway remodeling in asthma.
Spending on remodeling exceeded $214 billion.
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