Sentence examples for backbone portion of the from inspiring English sources

For all of the structures, the backbone portion of the amino acid is held in place by a hydrogen bonding network that is conserved between the two proteins.

One of the most conserved residues among the second-generation enzymes is Gln155, which is involved in interactions with the backbone portion of the amino acid substrate.

The His-tagged beta appendage domain expression construct is pGH491: Sequence encoding the C-terminus of mouse AP2 beta 1 (amino acids 592 951) was amplified using oGH1161-2 and recombined with the His-tag, T7 promoter and vector backbone portion of the His-tagged mu domain construct (pGH441 amplified with pGH571 and oGH339) using Gibson assembly.

Using the pRED-ET/RPSL-Neo counter selection system (Gene Bridges) the TetO array was seamlessly recombineered into BAC RP11 419E6, which contains approximately 170 kb of DNA corresponding to a gene desert on human chromosome 7. Tol2 sequence elements (Shakes et al., 2011 ) were then recombineered into the plasmid backbone portion of the BAC, together with a mammalian neomycin resistance cassette.

It also confirms a proposal that a Med7C-Med21-Med4-Med9 tetramer structurala structural backbone within the central portion of the Middle module (Lariviere et al., 2013).

These two residues are on opposite sides of a hairpin loop in the β-sheet forming the backbone of the NBD2 portion of the major catalytic MgATPase site 2 in SUR1.

The primary amplification primer sequences are present in the OCP backbone, not in the portion of the OCP that anneals to target, allowing optimized P1 and P2 pairs, to be used for many different targets.

The SUR1 NBdimerdimer homology model [ 17] places residue 1369 adjacent to a hairpin loop in the β-sheet that forms the backbone of the NBD2 portion of the major MgATPase catalytic site 2. Therefore, substitution of serine with an alanine at residue 1369 S1369AA) may alter the structure and/or flexibility of this region, leading to an increase in MgATPase activity of the KATP channel.

Probes can be designed against either strand of genomic DNA, and the backbone portion can also be varied.

The pelvis continues to reshape and expand to take up a huge portion of the backbone, the fibula reduces on the leg, the hand fuses, the claws and fingers reduce on the hand, the number of bones in the neck increases, and the sternum adds a keel.

Nonspecific electrostatic interaction of the MBD with the DNA backbone phosphates constitutes a significant portion of the total MBD interactions even for DNA containing mCpG.