Sentence examples for backbone of the substrate from inspiring English sources

AlkB creates an electropositive binding groove (Thr51 to Tyr55, Ser129, and Lys127) to anchor the phosphodiester backbone of the substrate.

The conserved R could either stabilize the intermediate during the nucleophilic attack or interact with the backbone of the substrate.

E303 also appears to modulate the positive charge density of the active site that is used to anchor the phosphate backbone of the substrate during catalysis.

During metabolism, the carbon backbone of the substrate is broken and recombined in different pathways, producing metabolites with different labeling patterns that can be detected through gas chromatography mass spectrometry (GC-MS) or nuclear magnetic resonance (NMR).

As observed in β-catenin crystal structures (for example Huber and Weis, 2001 ), a series of histidine and asparagine residues that originate from adjacent H3 ARM helices anchor the peptide backbone of the substrate by several short-distanced hydrogen bonds.

The structural changes may be accommodated in their tetrapeptide substrates, which lack residues beyond positionthat that may restrict the backbone conformation of the substrate.

In contrast, we argue that for the protein substrate used in our study, it is likely that the backbone conformation of the substrate will be held by extensive interaction of residues from P5 to positionsions.

In the crystal structure of the I-TevI DNA-binding domain bound to DNA representing either its homing target site or its target operator site, only one of the carboxy-terminal residues (Tyr242) makes a hydrogen bond to the phosphate backbone of the DNA substrate, clearly not providing any specificity to the interaction of I-TevI with its DNA substrate [ 47].

The nitrogen-containing structures like the imidazoles and the triazoles bind to the iron in the heme moiety of CYP-450, whereas the cyanobenzyl moiety present in the nonsteroidal AIs such as letrozole partially mimics the steroid backbone of the enzyme's natural substrate androstenedione.

Most lipases act at a specific position on the glycerol backbone of lipid substrate especially in small intestine.

Deuterium ions produced during the parallel oxidation reactions of the polymer backbone serve as the substrate for the chemical step of the quinone reduction reaction.