Sentence examples for backbone of the active from inspiring English sources

The Pastors Emergency Leaguee (Pfarrernotbund), headed by Martin Niemöller, was the backbone of the active opposition to the "heresy" of the German Christians.

Crystallographic analysis of EPSP synthase from Escherichia coli, in complex with shikimate/glyphosate at 1.5 Å resolution, revealed that binding of shikimate induces changes around the backbone of the active site, which in turn impact the efficient binding of glyphosate.

Further, to prevent the backbone of the active site from moving considerably during the gradient-based minimization, the Cα atoms are restrained to within 0.5 Å of their original positions.

Another key residue of UbcH5a is Asn, which has been proposed to stabilize the oxyanion of the tetrahedral transition state [ 27], and to play a structural role by hydrogen bonding to the peptide backbone of the active-site loop [ 28].

Accordingly, we performed an overlay of the InsS6-bound structures of BtMinpp and A. niger phytase based on the coordinates of the backbone atoms of the active site fingerprint sequence (RHGXRXP; residues 58 64 in BtMinpp) found in the A-a loop and those of the short region containing the presumed proton donor, E325 (HAE; residues 323 325) from the N-terminal region of helix l.

The carbonyl O atom of the P1 Hinteractedcted with the backbone NH group of the active site Ser220 and Nγ2 of Asn154 of subtilisin (Table S1).

Disrupting the backbone of the NETs with active DNase impaired the killing of B. pseudomallei by NETs from human neutrophils (Figure 4C).

Nevertheless, it does contact the amide backbone of the key, conserved active site lysine (K265) that binds the PLP as an internal aldimine, and is also thought to act as the base that removes the proton from C- α of L-serine.

Based on the modeling of an active peptide backbone in the active site of HMGR, two peptide libraries for constrained and unconstrained peptides were designed using different amino acids varying in hydrophobicity and electronic properties.

From the consideration of the structure-activity relationship of these novel compounds, we have attempted to rationalise the significance of the log P factor in the inhibition of ES and suggest that a log P requirement of approximately 3.5 aids the inhibition through the rapid expulsion of the carbon backbone from the active site.

Specifically, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), which form the backbone of highly active antiretroviral therapy, are all metabolized by (ie, are substrates of) the CYP450 enzymes, most by CYP3A4.