Sentence examples for backbone of a peptide from inspiring English sources

Conformationally constraining the backbone of a peptide into a macrocyclic ring often ameliorates these problems and allows for the development of a variety of new drugs.

For example, the following will target a range of unusually low bond angles across the carbonyl group in the three-atom backbone of a peptide, CA C N: [*.CA](.a1 105-110 C(.a1)(O N(.a1).a1

Incorporation of the 1,2-amino alcohol linker into the backbone of a peptide generated a conditional peptide that was rapidly cleaved at very low concentrations of sodium periodate.

Furthermore, to allow for easy incorporation in the backbone of a peptide ligand by automated solid-phase synthesis, we included orthogonal protective groups in the design of functionalised DAHB building blocks.

Indeed the structural similarity between a region of ampicillin (including the carboxyl group) and the backbone of a peptide chain have been used to explain the mechanism of action of β-lactam antibiotics.

A cleavable linker that can replace an amino acid residue in the backbone of a (poly)peptide or protein will allow cleavage of the backbone into at least two fragments upon application of a defined trigger, but will require accessibility of the cleavage site to the trigger.

In the conserved arrangement observed in class II MHC-peptide crystal structures, the backbone of a bound antigenic peptide forms six hydrogen bonds with the side chains of non-polymorphic DR1 residues Gln α9, Arg β71, His β81 and Asn β82 (Fig. 3C).

The number of exchangeable backbone amides (maxD) of a peptide was calculated as the total number of residues excluding proline residues and two fast exchangeable N-terminal residues.

We report the automated introduction of backbone protection to a peptide.

Although the structural pattern observed applies only to the backbone of the peptide, this does not imply a random distribution of the side chains along the cleft.

Depsipeptides are short chain amino acid sequences that contain at least one ester linkage in place of an amide bond in the backbone of the peptide chain.