Sentence examples for backbone modifications such as from inspiring English sources
Antisense probes used in FISH varied in repeat length, type and number of fluorescent labels and the presence of backbone modifications, such as PNA or LNA, and were used to enhance the binding efficiency and sensitivity of transcript detection.
The tool palette for aptamer synthesis includes not only natural DNA and RNA nucleoside monophosphates, but also non-natural building blocks with modifications at the 2′ position, such as 2′- O-methyl, 2′-fluoro-, and 2′- F-ANA; more profound sugar modifications, such as locked nucleic acid (LNA) and hexitol nucleic acid (HNA); or backbone modifications, such as phosphorodithioate linkages.
To overcome stability problems, chemical modifications such as phosphorothioate or methyl phosphonate are often applied to the nucleotide backbones [ 15].
Post-translational modifications such as glycosylation, phosphorylation were analysed.
The modifications such as the methyltransferases (EvaC, DvaC) and the aminotransferases (EvaB, DvaB) involved in maturation of vancosamine and its analogues in vancomycin, chloroeremomycin, balhimycin, and ristocetin do not qualify as secondary modifications since these modifications occur independently toward maturation of the sugar, before it is attached to the GPA backbone.
However, unlike modifications such as methylations, histone acetylation modifications are often considered redundant.
These epigenetic modifications include changes in DNA methylation and histone modifications such as acetylation and methylation.
Could this reflect altered ULK3 modifications, such as phosphorylation?
Different functional experiments demand different modifications of gene function, which includes gene sequence modification, such as knockin and knockout, and gene expression modifications, such as RNA interference (RNAi).
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Modifications to the oligonucleotide backbone such as 2′- O-methyl, 2′- O-methoxyethyl, and locked nucleic acids (LNAs) prevent SSO-induced antisense downregulation via RNaseH and also stabilise the oligoes towards nucleolytic degradation.
