Sentence examples for backbone modifications on the from inspiring English sources

The study was designed to evaluate backbone modifications on the inhibitory activity of PTR6154.

Discouragingly, backbone modifications of the siRNAs did not ameliorate this response (Kleinman et al, 2008).

One of the purposes of backbone modifications of the SSO is to prevent mRNA degradation by RNA interference.

To seek vancomycin analogs with broader antibacterial activity, effects of backbone modifications for the agylcon 2 on binding with d-Ala-d-Ala- and d-Ala-d-Lac-containing peptides were investigated by Monte Carlo/free energy perturbation (MC/FEP) calculations.

Recent studies of the effect of introducing noncanonical amino acid residues or amide bond mimics on ligand presentation in MHC complexes have provided insight into the importance of hydrogen bonding and secondary structure formation in T-cell-mediated recognition, which provides additional context for our efforts to evaluate the impact of α → β backbone modification on immunological responses.

Backbone modifications approaching the 3′-end on the sense strand were tolerated without compromising siRNA potency.

The largest effect was seen with the backbone modifications, suggesting this residue interacts with the DNA backbone of the translocating strand.

K194A displaced streptavidin four-fold faster on normal DNA than WT, but was slowed by all three of the modified oligonucleotides with the greatest effect seen with the backbone modifications.

When all three residues were replaced by alanine, the rate of streptavidin displacement was similar to WT for DNA, two-fold lower on abasic DNA, 14-fold lower on isp9 and two-fold lower on iC3 backbone modifications.

The basic siRNA expression cassette is described and initial studies on the effects of chemical backbone modifications that are being tested for applications involving exogenous delivery are reviewed.

Quesnel et al. introduced backbone modifications, aminomethylene (CH2-NH) surrogate into the same melanoma peptide MART-127 35. MART-127 35