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As seen in Fig. 5A, the Ins peptide backbone "leaps upward" from p6 to p8, relative to the β-sheet floor of the groove because residues 73W and 147W in the H2-Kd molecule, located across from each other, form a barrier over which the antigenic peptide must "climb" 29.
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LEAP starts by generating the backbone conformations of the target loop using the cyclic coordinate descent 'CCD' algorithm (Canutescu and Dunbrack, 2003), and then selects and optimizes them using the OSCAR energy function.
A backbone".
They are the backbone.
He wants backbone.
He has no backbone".
"Some people have backbone.
They have backbone.
The backbone bit.
"A lot of backbone.
She's my backbone".
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