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In addition to the possibility of dynamical coupling mediated through the backbone interactions of the α-helix, the side chain of Glu forms hydrogen-bonding interactions with several peptide groups of the 50′s loop that are mediated by a conserved buried water molecule, as analysed in detail in the recent high-resolution crystallographic analysis of FKBP12 [ 30].
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The Cβ atom is bound via backbone interactions of Ser207.
The reconstitution of kcat indeed suggests intramolecular signaling of acceptor-stem backbone interactions to the catalytic center, but the other measurements indicate that this subregion of the protein RNA interface does not operate as an independent module but instead depends on other portions of the RNP for its function.
This situation points to electronic and topologic nucleotide's backbone interactions control of the stability profile of paromomycin RNA complexes.
Similar to the PAD4 substrate peptide interaction, the majority of the interactions between the substrate peptide and PRMT5 are mediated by peptide backbone interactions, rationalizing the lack of strict sequence specificity.
These models also permitted the interpretation of the driving forces of such folding process, indicating that topologic/topographic protein backbone interactions control the stability profile of wild-type Arc and its alanine mutants.
It is possible that the addition of vinyl ether linkage decreases the attraction of adjacent lipids by several mechanisms such as disrupting the optimal glycerol backbone interactions or changing the orientation of lipids with respect to each other.
Thus, the two HhH motifs are observed to make DNA backbone interactions with each end of the incised DNA strand.
Mutation N230G affected GSH binding possibly due to the lowering of backbone interaction between the amino acid at position 230 and GSH.
However, the average M-O distances of Li+- and Na+-DB18C6 in aqueous solution are nearly the same with those in the gas phase, which seems because the folded DB18C6 backbones hinder the interactions of the metal cations with the water solvent.
In addition to the typical β-sheet backbone interactions, a number of EhPAK4 side chains contribute to a predominantly hydrophobic interface with EhRacC.
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