By conjugating together four copies of 'T7', using an avidin backbone in the first-generation design, VT was developed with the aim of tetramerically binding and clustering Tie2 receptors in an 'Ang1-like' manner to activate Tie2 signaling (Van Slyke et al, 2009).
We used a computational design procedure to create new backbone conformations in the second turn of protein L. The Protein Data Bank was searched for alternative turn conformations, and sequences optimal for these turns in the context of protein L were identified using a Monte Carlo search procedure and an energy function that favors close packing.
Here, we present our study on the effect of an inversion of backbone stereochemistry in the second N-terminal position on the self-assembly of aDrs peptide (Fig. 1).
Therefore, the unique sequences that were annotated as responsible for the formation of the SS backbones in the first two stages of the pathway were first screened.
This brings to a concern of an appropriate backbone NRTI in the first-line regimen in resource-limited countries.
All these two trials demonstrated survival benefits of S-1 in advanced gastric cancer, which holds the promise of becoming a backbone agent in the first-line regimen in treating advanced gastric cancer.
The two parent homopolymers prepared from the constituent monomers, which differ only in the length of the coupling chain, exhibit, in one case, a preferential alignment of the mesogenic units parallel to the polymer backbone (NIII) and, in the second case, an alignment of the mesogenic units perpendicular to the backbone (NI).
The stress strain relation is built on the basis of well-known extended Masing's rules in which the scaled backbone curve used in the second rule is replaced by a more general function called the hysteresis function.
The CDS tree is used as a virtual backbone for efficient data aggregation scheduling in the second phase.
The peptide fragments are bound by interactions with the peptide backbone and amino acid side chains in the second exon-coded part of HLA-DRB1 (DRB1-e2), termed antigen recognition sites (ARS).
