Recent studies using H/D-MS have shown that distinct regions of IgG1 mAbs experience significant changes in backbone dynamics in response to specific physicochemical alterations, varying solution conditions, or exposure to different environmental stresses.
As previously stated, several transcripts in the terpenoid (isoprenoid) backbone biosynthesis pathway are reduced in response to hypoxia.
The academic director of an Israeli-financed terrorist-research body, Reuven Paz, recently said that a "variety of associations in London...could serve as the backbone of terrorist Islamist groups".Largely in response to these sorts of protests, Britain is toughening its laws on terrorism.
The backbone of loop residues 27 30 shifts in response to contacts with CycT1 250–261 for two complexes in the a.u. Based on mass spectrometry and electron density, the baculovirus-expressed Tat, like Tat expressed in HEK293T cells (Jäger et al., 2012), is N-terminally acetylated.
The threonine glycine biosynthetic pathway is predicted to be part of a so-called high-flux backbone of metabolism, containing sufficient flux for providing growth homeostasis in response to growth limiting perturbations [ 35].
This approach could provide a mechanistic insight that occurred in response to CS exposure, which is reflected from the differential network backbone values.
In response to a single triggering event of a decrease in pH, the amine backbone undergoes a sharp hydrophobic−hydrophilic switch.
Free energy landscapes for backbone torsion and sugar pucker degrees of freedom in the DNA are used to understand their behavior in response to the base flipping perturbation.
While the total numbers of deployed tanks fluctuated over time, the armored units fielded by the United States served as the backbone of the military capability of NATO, an alliance entered into in 1954 between the United States, the United Kingdom, France, West Germany and twelve other European nations in response to fears of Soviet aggression.
Finally, genes uniquely up-regulated in response to ionizing radiation included several proteasome subunit genes, which may indicate a particular requirement for protein turnover, perhaps in response to protein backbone cleavage, or alternatively this might reflect the critical role of the proteasome in DNA repair [ 32].
