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The major difference between 2a and 2b arises in the orientation of the terminal methyl groups of the ligand backbone in relation to the AlIIIN3S plane.
Although such interactions involving the main-chain atoms of the substrate (or inhibitor) are not directly responsible for defining specificity, they are likely to be of great importance in correctly positioning the substrate backbone in relation to the catalytic residues.
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The effect of the modification of the molecular structure on the stiffness of the polymeric backbones in relation to the diffusion coefficients of typical rubbery and glassy silane and siloxane polymers at different temperatures was investigated.
The therapeutic regimen was analyzed in relation to the backbone (a combination of two NRTIs) and the third drug (usually a protease inhibitor or an NNRTI, raltegravir, or maraviroc).
Thermal properties and viscosities have been investigated in relation to molar mass, backbone structure and terminal functionality; comparisons are made with related saturated and unsaturated systems, and with polymers containing terminal ionic functionalities, formed by alkylation, protonation, or coordination with Cu II), Ni II) and Fe III) chlorides.
One possible concern in this approach is the fact that the synthesis and handling of a catalyst containing a relatively strong acidic group together with the acid-labile acetal moiety might be a major limitation in relation to other chiral backbones.
Our results provide also possible indications regarding the chemotherapeutic backbone associated with trastuzumab, a still open issue in relation to efficacy and safety, especially considering long-term outcomes.
And in relation to America?
In relation to energy companies, Which?
In relation to interest rates?
What was it in relation to?
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