The diversity of the possible side chains of a xyloglucan backbone determines the functionality and physico-chemical properties, like water solubility or gelling capability, therefore; currently tamarind xyloglucan is used e.g., as a gelling agent, an emulsion stabilizer or as a food thickener [ 4].
Unlike supramolecular sheets there are a very few examples of peptide sub-units that can be used to construct supramolecular helical architectures using the backbone hydrogen bonding functionalities of peptides.
An efficient synthesis of siRNAs modified at the backbone with a triazole functionality is reported.
By contrast, in this work citronellol was used as an ester unit linked to the carboxylic acid moiety of the amino acids glycine, alanine, valine, and phenylalanine that were in turn linked to the polymer backbone through the amino functionality.
Thermal properties and viscosities have been investigated in relation to molar mass, backbone structure and terminal functionality; comparisons are made with related saturated and unsaturated systems, and with polymers containing terminal ionic functionalities, formed by alkylation, protonation, or coordination with Cu II), Ni II) and Fe III) chlorides.
Importantly, the peptidic backbone and the diazoketone functionality in [18F]2, responsible for selective and irreversible binding, respectively, appear metabolically stable.
Initially, substrate 2 a was chosen as a model system to test our concept; its precursor 1 was accessible on scale, 7 the spirocyclic pyrrolidinone backbone would place reactive functionality in close proximity, 8 and its synthesis by cross metathesis would provide a point of diversity if the desymmetrization proved successful.
This monomer contains a dioxolane-protected keto group that will allow liberation of the ketone functionality in the backbone once construction of the oligomeric backbone is complete.
It was observed that for the material with a spherical morphology GSTe is increasing with the number of branch points β (each branch point consists of a PI backbone segment, depending on the functionality one, two or four grafted PS arms).
Binding additional molecules to a nucleic acid backbone can expand the chemical functionality of nucleic acid based scaffolds.
