Sentence examples for backbone for the binding from inspiring English sources
DNA and histones represent the major components of NETs and provide the backbone for the binding of neutrophil granule components (e.g. myeloperoxidase and elastase) that may play an antimicrobial role [36].
Amidase treated peptidoglycan or peptidoglycan fragments are no longer ligands for PGRP-SA due to the absolute requirement of both the stem peptide and the sugar backbone for binding.
The phosphate backbone of DNA provides a negatively charged surface for the binding of basic side chains (Lys, Arg) of proteins.
The structure of fumonisin B1 13 and the characteristics of the inhibition suggest that the aminopentol backbone competes for binding of the sphingoid base substrate, whereas the anionic tricarballylic acids may interfere with binding of the fatty acyl-CoA.
It may well be the case that overall C2 symmetry can aid in the association of a DNA binding molecule (i.e., compound 1) because such symmetry ensures an initial encounter with DNA will always involve the proper backbone orientation for binding to a preferred site.
In many binding energy calculation methods including FoldX, it is commonly assumed that protein backbone structures are fixed and only a finite number of side chain conformations (rotamers) are considered for calculating the binding energy.
Hence, the discovery of efficacious MMP inhibitors without strong zinc-binding functional moieties is a very active field of research toward the generation of clinical treatments for those serious conditions.[ 16] Peptide bonds of the protein backbone represent the ubiquitous binding motif for small molecules to modulate a biological target.
To seek vancomycin analogs with broader antibacterial activity, effects of backbone modifications for the agylcon 2 on binding with d-Ala-d-Ala- and d-Ala-d-Lac-containing peptides were investigated by Monte Carlo/free energy perturbation (MC/FEP) calculations.
However, ring‐opening of reducing end monosaccharides limits applicability to very short oligosaccharides (di‐ and trisaccharides) and, potentially, to N‐glycans recognized by proteins such as Pisum sativum agglutinin (pea lectin) that require both intact core and backbone regions for strong binding.
