First, even though the CPMG experiments conducted here probed changes in the backbone environment, the conformational changes are mostly at the side chain level.
Data centers, which are the backbone of corporate computing environments, now need far fewer physical machines.
Internet Protocol (IP) over Wavelength Division Multiplexed (WDM) networking technology with Terabits per second bandwidth become a natural choice for the future generation internet networks (Optical Internets), wide area network (WAN) environments and backbone networks due to its potential ability to meet rising demands of high bandwidth and low latency communication.
The absence of NMR CSPs for the positively charged residues in ZnF1 upon RNA titration (Fig. 6A) is likely due to similar chemical environment for backbone amide protons when surrounded by water or interacting with RNA, and is also indicative that the interactions between ZnF1 and RNA is mainly electrostatic and likely nonspecific.
The primary use of only one type of structural lipid may have been driven in part by the difficulties of reconciling metabolic pathways that use different chiral forms of the lipid glycerol backbone, with the mesophilic environment removing any intrinsic benefit of ether-linked lipids.
FTIR analysis indicated the cleavage of aryl-ether linkages in quaternized PAEs under high pH environments, while no backbone degradation in quaternized PP was observed.
In general, the side-chains of amino acids probe a different environment from that of the backbone, and charged side-chains probe a different environment from that of hydrophobic side-chains.
Since the PIPn ligand motifs used in this analysis lack the membrane environment and glycerolipid backbone, yet still exhibit high-affinity protein binding, these results narrow down the structural requirements for Akt recognition.
In acidic pH environment, the drug is delivered into the cytoplasmic compartment of the cells and in this environment the polymer backbone is detached from the drug and it therefore destabilizes the endosomal membrane for the controlled delivery of the drugs.
Signals in these spectra are highly sensitive to the local chemical environment of the backbone amide groups.
