Sentence examples for backbone dynamics of the from inspiring English sources
By representing the backbone dynamics of the folded protein by three distinct regimes, it is possible to decompose its seemingly complex dynamics, described by a stretch exponential decay of the backbone motions.
Based on the NMR structure and the backbone dynamics of the single chain NpuDnaE intein, we designed a functional split variant of the NpuDnaE intein having a short C-terminal half (C-intein) composed of six residues.
In particular, increased backbone dynamics of the transmembrane helix relates to its increased ability to flip lipids with phosphatidylcholine and phosphatidylserine headgroups, whereas a more rigid helix favors phosphatidylethanolamine flip.
To analyze the backbone dynamics of the I214V mutant of RaPrPC(121 228), we performed 15N relaxation measurements using NMR spectroscopy.
By making use of our previously assigned backbone NMR resonances of both yeast and human PCNA trimers [11], [12], we performed an amide hydrogen/deuterium solvent exchange analysis in order to assay and compare the local backbone dynamics of the two proteins.
Specifically, this work reveals differential changes in backbone dynamics of the leader linker region of the VC riboswitch that are modulated by salt, magnesium, and glycine.
As part of our efforts to use NMR techniques to assist in deciphering the enzyme's structure-function relationships and developing specific small molecule inhibitors, we have determined the solution structure of an engineered subdomain 2 of the NS3 RNA helicase of HCV, d2Δ-HCVh, and studied the backbone dynamics of this protein by 15N-relaxation experiments using a model-free approach.
In SaSrtA the backbone dynamics of this region change upon binding to Ca2+, which activates catalysis [48], and it has been shown to rearrange in the presence of the LPXTG substrate, forming a 310-helix that helps generate a binding pocket with the underlying β-sheet [31].
To further ascertain the intrinsic Ub-binding properties, we compared the backbone dynamics of AT3-UIM12 in the presence and absence of Ub.
In this study, we have probed the backbone dynamics of HbI to investigate the role of conformational entropy in the cooperative mechanism of carbon monoxide binding.
Backbone dynamics of residues in the π-helical segment appeared to be correlated, at pH 9. Samples also were frozen to examine the polarity and proticity of the local environments, the effect of the local environment on intrinsic relaxation, and dipolar relaxation by two symmetries of catalytic iron.
