Sentence examples for backbone damage from inspiring English sources

For example, we observed similar results from both capillary electrophoresis and sequencing analysis that the total amount of RT- stopping damage exceeds scissile backbone damage by at least 6-fold.

The purchase will give Johnson & Johnson's DePuy unit an artificial disk used to repair backbones damaged by injury or disease.

(iv) In general, the increase in the fraction of double-stranded regions elevates the resistance of RNA backbone to UV-damage [ 25], as well as to hydrolysis [ 26].

It is noteworthy that modern chlorophyll-carying proteins, besides being involved in the storing and utilization of solar energy, retain the ability to protect cell DNA from the residual UV component of solar radiation [ 413], thus resembling the nucleobases that, in addition to serving as the letters of genetic code, continue to protect DNA and RNA backbones from UV damage [ 159].

Functionalization conditions were first defined that did not damage the backbone of low polymer content (20%) monoliths allowing high-throughput chromatographic separations.

It appears therefore that nitrogenous bases protect the pentose-phosphate backbone from the UV damage.

Since the large backbone is susceptible to damage during the transformation procedure, the used batch of pAdEasy-1 transformed BJ5183 cells was tested by restriction enzyme analysis and the ability to rescue infectious adenovirus from recombinant plasmids.

These changes in the DNA backbone are harmful, and DNA damage sensors such as DNA-PK, p53, ATM and ATR recognize these damaged sites and repair the abnormal DNA [21], [22].

Human Ape1 is a multifunctional protein with a major role in initiating repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage.

Shifts at peaks 1236 cm-1 and 1074 cm-1 suggest denaturation of the phosphodiester backbone of nucleic acids, thus damage to DNA and RNA.

As network hubs are a central part of a high-capacity backbone for global brain communication, damage to their connections would have the effect of reducing the ability of the brain to efficiently transmit information, by increasing the number of connections it takes for one region to communicate with another (van den Heuvel et al., 2012).