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Meanwhile Sprint also controls the No. 4 wireless company and the No. 2 Internet transport, or backbone, carrier.
Deutsche Telekom has also cast an eye at PSINet Inc., the Internet backbone carrier, though no talks are under way, the executives said.
When Ethan sends Andrew an email, that email will likely travel from Ethan's ISP up to a satellite, down to the United States or Europe, over at least one backbone carrier, up to another satellite, and back down to Ghana, where it ends up with Andrew's ISP.
But Web sites don't go down because a backbone carrier like MCI WorldCom didn't have enough fiber; they go down because there wasn't enough fiber in the right places.
One strategy to overcome some of these issues is to conjugate toxins to a polymeric backbone carrier via bonds that are selectively cleaved in endolysosomal compartments, so that the immunotoxin drug is released on reaching the target cell.
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Ms. Perey said that image quality suffered partly because the Internet's backbone carriers inadvertently trash streaming video signals originating from a competitor by starting and stopping the data stream.
And the Agilent device, known as a transceiver, does not rely on the costly, complex optical-network formats that telephone companies and Internet backbone carriers typically require to achieve such transmission speeds.
Backbone carriers compete on price, while the lords of the last mile maneuver in Washington.
This hybrid approach was rationally designed to comprise cationic HPMA copolymer backbone as drug carrier, doxorubicin (Dox) as model drug, hydrazone bond as drug spacer, FQSIYPpIK (FQS) peptide as αvβ3 targeting ligand and 2, 3-Dimethylmaleic Anhydride (DMA) as a shielded/deshielded cationic group.
Abetimus is a synthetic water-soluble molecule consisting of four double-stranded oligodeoxyribonucleotides each attached to a nonimmunogenic triethylene glycol backbone, a proprietary carrier platform [ 28].
We demonstrate our method on a simple triangular network topology and characterize a network contract graph derived from more than 10 major carrier backbones and new entrant networks.
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