The methodological two-fold approach intends to form a solid backbone based on: (i) the systematic and structured empirical characterization of the model; and (ii) the conceptual structure definition according to the agent-based model documentation protocol – Overview, Design concepts and Details.
Its main structural components consist of a thiazolidinedione (TZD) ring covalently linked to a polyphenolic backbone, based on compounds derived from the bark of plants of the Pterocarpus genus.
That is, whereas MLST is an approximation of the mutation rate of the genomic backbone based on sequence analysis of a relatively small number of housekeeping genes, analysis of whole genome differences is a measure of both the rate of mutation and horizontal gene transfer that exists among this species.
In this paper, we develop a hybrid clustering charging algorithm (HCCA), which firstly constructs a network backbone based on a minimum connected dominating set built from the given network.
The mPE and post-implant polymers were designed to have an m/z ratio extrapolated from the FT/MS data (Figure 3a and Figure S2) and all the polymers had at least 16 carbons in their backbone based on published structural requirements for a TLR1/2 ligand [17].
Lenalidomide plus rituximab was felt to be a safe and promising backbone based on available data.
SPAN [18] is an example of a backbone-based coarse-grain conservation scheme, where each node makes local decision to go into sleep or join backbone, based on its own energy and estimation that how many of its neighbor will benefit from it being awake.
Several types of modified synthetic AOs fit these criteria: AOs with backbones based on PMO [ 24, 36] and with modifications to the 2′ position of RNA, such as 2′OMePs [ 25, 37], are RNase H inactive and display high nuclease resistance and an affinity for target sequences.
It has been demonstrated based on the suggestion of Joyce et al. (1987) and proposed chemistry (Nelsestuen 1980; Tohidi and Orgel 1989) that backbones based on acyclic nucleoside analogs may be more easily obtained under reasonable prebiotic conditions, for example by the reaction of nucleobases with acrolein obtained from mixed formose reactions (Cleaves 2002).
