Thus the peptide backbone assumes a conserved conformation at the termini and bulges out from the cleft in the center.
However, as a simple comparison, performing traditional DEE separately for each of the 3888 backbones (assuming similar CPU times for each backbone), would require ∼120 days on the same number of processors.
At low temperatures, far below the melting temperature, the polysiloxane backbones are assumed to pack in an orthorhombic lattice, with the n-alkyl side chains in a planar all-trans conformation and oriented perpendicularly to the backbone.
Since BSs are already connected to each other over a high-speed and more reliable wired backbone, we assume that they can share information about the system and perform joint transmission and scheduling.
Attaching them to proteins (via TG2) provides an elegant way to manipulate polyamine concentrations (organic cations) locally to be able to alter propensity for DNA (highly negatively charged due to phosphate backbone) to assume a compact (silenced) conformation.
Essentially all possible backbone conformations are assumed.
Finally, in the condensation of the fatty acids to the glycerol backbone, it is assumed that 1 ATP is consumed for each fatty acid.
In most of protein design models (Roberts et al., 2012), the backbone structure is assumed as a rigid body, and only side-chains are allowed to rotate among a finite set of discrete conformations, called the rotamer library.
The value VD = 0.97 kcal mol−1 obtained in the present study for the σ-conjugated polysilanes nearly equals the VD ≈ 1.1 kcal mol−1 estimated by Schweizer for the analogous π-conjugated carbon-backbone polymers, assuming similar physical conditions.
Also, backbone connectivity is usually assumed to be guaranteed by a fixed backbone infrastructure, a very limiting assumption in a dynamic wireless scenario.
