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The two main chain dihedral torsion angles that describe the rotations of the polypeptide backbone around the bonds between N-C α and C α-C were identified by Ramakrishnan and Ramachandran [ 1].
The binding of the RNA duplex is stabilized by hydrogen bonds and electrostatic interactions between U1-C and the RNA backbone around the splice junction but U1-C makes no base-specific contacts with pre-mRNA.
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Now, after Mr. Manry's splendid feat, we feel sure that there will be a stiffening of backbones around the copydesks everywhere-a certain rake to the angle of the eyeshade, a certain new snap to the snip of the scissors.
However, these treatments also increased reactivity in the WT hSOD1 mice and thus we attribute C4F6 reactivity in this case to relaxation of the WT SOD1 structure to loosen the tight bend in the backbone around amino acids 90 93.
Moreover, although substrates/pseudosubstrate and products independently close the active-site cleft, only the substrates substantially decreased the backbone flexibility around the B helix.
During this period, Verizon transformed into a premier global network company by building a nationwide wireless network, deploying high-speed fiber broadband direct to homes, and expanding Verizon's global Internet backbone network around the world.
The anisotropy decay of fluoroscein 5-maleimide, conjugated to a site of cysteine substitution (K81C) in the small lobe of the C subunit was used to assess the local backbone flexibility around the B helix.
The tail complex bound to T1 was further refined using small backbone changes around the main cluster obtained in the MD above.
IRMPD of mononitrated cytochrome c was more efficient than ECD and produced several backbone cleavages around the possible sites of nitration, Figure 3b.
The presence of a truncated patI pseudogene, the loss of the other components and the absence of backbone genes around the cluster, suggest that these genes do not function in the patulin biosynthetic pathway.
The overlay in Fig. 1 shows the strong similarity in backbone fold around the QB site in the two complexes and consistency in the binding conformation adopted by terbutryn (and see Supplementary Fig. 1 for a colour, stereo view of this overlay).
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