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The main protective roles of GSH against oxidative stress are: its role as a cofactor of several detoxifying enzymes against oxidative stress, e.g. glutathione peroxidase (GPx), glutathione transferase (GST) and its role in regenerating the most important antioxidants, vitamins C and E back to their active forms [9], [10].
It has a role in converting vitamins C and E back to their active forms.
The enzymes are recycled back to their active, reduced form by thioredoxin/thioredoxin reductase (Trx/TrxR) or glutathione/glutathione reductase (GSH/GR) systems using reducing equivalents from NADPH.
GSH has been reported to have protective roles against oxidative stress through scavenging hydroxyl radical and singlet oxygen directly detoxifying H2O2 and lipid peroxides and also regenerate important antioxidants, Vitamins C and E, back to their active forms [ 2].
The main protective roles of glutathione against oxidative stress are that it can act as a co-factor for several detoxifying enzymes, participate in amino acid transport across plasma membrane, scavenge hydroxyl radical and singlet oxygen directly, and regenerate Vitamins C and E back to their active forms (Masella et al 2005).
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