These are ambitious goals that can be reached only by highly cooperative engagement of basic immunologists, vaccinologists, and clinical researchers or in other words, by translation from basic immunology to vaccine research and development, as well as reverse translation of insights from clinical trials back to hypothesis-driven research in the basic laboratory.
Back to my original hypothesis.
Concerning the weakly supported nodes within the Poronota (Fig. 2), one could hypothesize that porose areas still can be traced back to one MRCA, a hypothesis clearly rejected by our BF comparison of alternative phylogenetic hypotheses (hypothesis 3, Table 2).
Researchers think SOA may also threaten human health, but they're just starting to gather evidence to back that hypothesis.
Back to the efficient markets hypothesis.
If the splits implied by these fossils are in fact more ancient than currently believed, this might pull the genetic date far enough back to make the hybridization hypothesis unnecessary.
Ronald Reagan, of course, brought us back to the efficient-market hypothesis with its faith in laissez-faire — a faith embraced, to one degree or another, by all of Reagan's successors as well.
Which leads back to looking beyond the hypothesis.
These candidate SNPs can then be taken back to case control studies for hypothesis-driven G × E analyses.
This concept dates back to the time-on-task hypothesis by Carol, which claims that it is time dedicated to studying that determines the learning outcome [ 9].
The Lemniscea hypothesis goes back to Lorenzen [ 23] and favors a sister group relationship of bdelloids and acanthocephalans, with the Monogononta and Seisonidea placed basally to the Lemniscea (Fig. 1A).
