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Fluid return to the vascular space is only minimal due to resorption back into the vascular system and mainly occurs by drainage back through the lymphatic system [36].
Simvastatin and amitriptyline function as substrates of P-glycoprotein, which is an important component of the blood-brain barrier which transports drugs back into the vascular space [30], [31].
Laterally localised PINs promote the lateral auxin flux from the external cell files back into the vascular bundle, closing a reflux-loop.
Fluid return to the vascular space is only minimal due to resorption back into the vascular system and mainly occurs by drainage back through the lymphatic system [ 36].
Due to the laterally localised PINs, at any vertical position a small fraction of the auxin within the external cell files fluxes laterally back into the vascular tissue, while a large fraction continues its flux upwards.
Timely fluid shifts back into the vascular compartment to achieve a negative fluid balance seem to have major prognostic relevance in critically-ill patients with acute kidney injury, since several studies have shown that fluid overload in these patients is associated with increased mortality [ 40, 41].
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