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Cocaine-addicted baboons treated with the molecule stopped injecting themselves, with no sign of becoming hooked on the treatment instead.An even more intriguing approach to cocaine addiction uses the immune system which can be coaxed into producing antibodies to just about anything to attack drugs.
Mitochondrial dysfunction has been described in rat models of sepsis [ 29], and a study in baboons treated with live Escherichia coli found decreased complex I/II activities in heart mitochondria [ 30].
Evaluating 12 baboons treated with placebo or etanercept, a significant decrease in the amount of spontaneously occurring active endometriosis was observed in animals treated with etanercept after 8 weeks of treatment [ 92].
Taylor and colleagues [ 22] found a decreased mortality rate in septic baboons treated with aPC and Roback and colleagues [ 23] showed an increased survival rate in rabbits with LPS-induced meningitis that were treated with aPC.
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This finding mimicked previously reported changes in the epithelium of baboon tracheal rings treated with CARDS toxin [27] but is the first demonstration of the ability of rCARDS toxin to induce vacuolization in vivo.
Organ function in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody.
Accumulation amount of Ringer's solution over time, hematocrit and total plasma protein concentration in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody (L-SEL-Ab).
Baboons were treated in accordance with guidelines established in the Weatherall report "The use of non-human primates in research".
Similar results have been obtained treating baboons with a monoclonal antibody (mAb) to TNF α [ 94].
Five animals were infected with S. haematobium and had no further treatment, and the main experimental group of 10 baboons was infected with S. haematobium and also treated weekly with 5 mg/kg BBN for up to 2½ years.
NT4 treated baboons had gained 1.65±0.31 kg (mean±SEM) while vehicle treated baboons lost 1.36±0.47 kg of total fat mass (Fig. 4c, P = 0.01, two-tailed Student's t test with Welch correction).
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