The maturation of the hypothalamic-pituitary-gonadal (HPG) axis underlies the development of puberty in mammalians [1] [4].
We found that the gradient in cell size along the developmental axis underlies this spatially different tissue-scale diffusivity.
Inter-individual differences in HPA axis underlie differential vulnerability to neuropsychiatric and metabolic disorders, although the basis of this variation is poorly understood.
108 An emerging line of evidence suggests that exercise targets SIRT1, and the resulting activation of the SIRT1/PGC-1α axis underlies many of the beneficial effects associated with exercise.
In conclusion, we postulate that: 1) The Drosophila PAX7-FOXO1 model is uniquely configured for the quick uncovering of new RMS genetic effectors with one simple genetic screening cross; 2) a putative PAX-FOXO1 →MEF2/MaxisRMIND axis underlies A-RMS; and 3) Drosophila conditional expression models are an efficient and powerful gene discovery platform for the rapid dissection of human disease.
Interestingly, the interaction between short telomeres and T2DM risk appears to involve mitochondrial dysfunction as an intermediate process, suggesting a mitochondrial axis where underlying gene regulation of telomerase-related pathways is important.
Thus, alterations in cytokines and the HPA axis may underlie stress-induced enhancement of hyperalgesia.
36– 40 Thus, the hyperactivity of the C1 adrenal and dorsal raphe 5-HT axis should underlie the AN syndrome, which also includes raised plasma levels of both adrenaline and f5-HT.
Studies also have found that alcohol-related neuronal adaptations on basal-state physiology, including upregulated ANS and HPA axis systems, underlie high alcohol craving, poor clinical outcome, and relapse vulnerability by disrupting physiological arousal (Breese et al. 2011; Seo et al. 2013; Sinha et al. 2011).
Then, a moving object index (e.g., a TPR-tree) is created based on each DVA, using the DVA as an axis of the underlying coordinate system.
