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PI3K pathway inhibition is an attractive axis in the development of targeted treatments in GBMs.
Recent findings suggest an important influence of the GH1/IGF1 axis in the development of breast cancer.
These results show a direct association between both systems (sympathetic nervous system and renin-angiotensin-aldosterone axis) in the development of arterial hypertension in VAV-3−/− mice.
Indeed, Sims et al (2010) recently argued a predominant role for the HMGB1 RAGE axis in the development of inflammation and cancer.
The authors reviewed research pertaining to each hypothesis and concluded by highlighting findings from various independent studies that have implicated cytokines, 5-HT, and the hypothalamic pituitary axis in the development of cancer-related fatigue.
Recently, a polymorphism in the CD40 gene was found to be associated with atherothrombotic manifestations in RA patients, thereby supporting the implication of this axis in the development of accelerated vascular complications in RA [ 61].
Similar(53)
Remarkable anisotropy between the directions parallel and perpendicular to the chain axis is found in the development of structure formation.
Hence, the SIRT1-p53 axis is implicated in the development of various cancers.
Targeting the gut brain food hedonic axis is important in the development of future non-surgical treatments of obesity.
It has been suggested that stress-induced activation of the hypothalamic-pituitary-adrenal axis may result in the development of metabolic abnormalities and depression (12).
Their findings indicate a key role of the S1P-S1PRs axin in the development and maintenance of immunity [ 18, 19].
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