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Cellular machinery dedicated to regulating mRNA processing, localization and translation is often employed in the generation of developmental asymmetry as during the establishment of embryonic body axes and specification of the germline (Martin and Ephrussi 2009; Richter and Lasko 2011).
In particular, mRNA localization and local translation are heavily used in the establishment of regional differences within the oocyte and early embryo that are necessary for formation of the body axes and the specification of the germline.
During animal gastrulation, the specification of the embryonic axes is accompanied by epithelio-mesenchymal transition (EMT), the first major change in cell shape after fertilization.
88 The formation of the left right (L R) axis is preceded by the specification of the dorso ventral (D V) and A P axes.
Wingless signalling plays a pivotal role in specification of the proximal-distal and dorsal-ventral axes of the leg disc [15], [42] [44], and has also been reported to control muscle development in the thoracic portion of the wing disc [25].
At around E10.5, neuronal progenitors receive positional information along the anteroposterior and dorsoventral axes, and a number of homeodomain proteins are key molecules for this specification [37].
Localized to either an individual cell or group of cells, embryonic organizing activity induces the specification of other cells in the embryo and can influence formation of body axes.
Specification changes.
"An interface is a specification.
First the axes.
Both axes are logarithmic.
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