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The aim of blinding is to reduce the risk of unrecognised bias being introduced by participants when they are aware of intervention allocation.
Recruitment of patient participants into professional-cluster trials can result in selection bias from the selective recruitment of patients by individuals who are often aware of intervention allocation (for example, Farrin 2005 [ 11]).
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The post-implementation questionnaire survey showed that adult women in the intervention villages were considerably more likely than those in control villages to be aware of intervention-related HWWS messages, with all differences receiving strong statistical support (p < 0.05) (Table 3).
Qualitative approaches to examining interventions were also included to assist in reporting on the evolution of this field of inquiry: we believe that clinicians and researchers will benefit from being aware of interventions even if they are only in the early stages of development.
Other limitations of the study are that therapists will become aware of the intervention, and contamination between intervention and control group therapists can not be completely avoided.
Therefore, in designing educational policies and different educational interventions we should be more aware of the intervention of this major factor in children's success.
The process of randomisation is also shown in Figure 2. In this trial blinding of the patients is not possible as they either do or do not receive the material belonging to the interventions, and are therefore automatically aware of the intervention group.
The control classes within the schools may have become aware of the intervention implementation processes by knowledge transfer from the intervention classes, either inadvertently or intentionally as students may have discussed their experiences.
The trial is considered open-label because both the research facilitator who delivered the intervention and the participants who received it were aware of which intervention was being delivered.
The closely aligned theoretical domains 'knowledge' and 'skills' refer to whether individuals are aware of an intervention, and their ability (acquired through practice) to perform the intervention.
The intervention was comprised of seven sets of social-marketing materials placed in the intervention pharmacies at quarterly intervals, and pharmacy staff was aware of the intervention.
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