Sentence examples for avoided the activation of from inspiring English sources

In the present study, the hepatic levels of phosphorylated forms of p38MAPK are significantly lesser in the curcumin-treated rats when compared with those in the control group, suggesting that curcumin treatment avoided the activation of MAPK signaling cascade with the prevention of stress in the liver of diabetic rats through which it has prevented the liver injury in STZ-induced diabetic rats.

Normally, these prosurvival p53 activities would be tightly controlled in order to avoid the activation of an improper response, but, clearly, hijacking the metabolic functions of p53 under conditions of sustained stress in which repair or recovery is not possible could help rather than hinder tumor development.

If the ACh is released in the matrix, the high AChE level might rapidly terminate the ACh signal and avoid the activation of the nicotinic receptors.

Our results using genomic RNA from HTNV, CCHFV and BDV establish the generation of 5'-terminal monophosphates as a novel strategy to avoid the activation of the IFN system.

Targeting CD40 instead might avoid the activation of platelets, which express CD40 ligand.

Like the present study, they used concentrations of genotoxicants that induced minimal toxicity (10 30%) so as to avoid the activation of cell death pathways.

Because the R-Avr interaction is highly specific, a mutation in the Avr gene may be sufficient to avoid the activation of plant defence.

Many efforts have been made to avoid the activation of innate cellular immunity for safe application of RNAi in a clinical setting.

A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death.

Thus, finding a way to promote effective Aβ clearance in these cells, while avoiding the activation of proinflammatory and neurotoxic pathways, should prove an attractive target for AD therapies.

In most cell types, low binding of monomeric or dimeric STIM1 K-rich domain to PM lipids restricts STIM1-mediated ER PM contact formation to significant depletion of ER Ca2+ and avoids the activation of STIM1 by small fluctuations of the ER Ca2+ levels.