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Avoidance of overlapping toxicities is a priority in the selection of suitable Pim inhibitor drug partners, with the propensity of Pim inhibitors to induce cardiotoxicity a key consideration.
Indeed, some of the guideposts in combining chemotherapeutic agents (e.g., definition of MTD and avoidance of overlapping toxicities) might not be suitable when combined with biological agents that have low-toxicity profiles when used at the low-dose range.
Similar(57)
The other advantage of uniform segmentation is the avoidance of clusters' overlapping.
Eisenman is an artist of overlapping sincerities.
Separation of overlapping partials.
We are increasingly living in a time of overlapping spaces, and overlapping identities.
The confidence interval of the drought avoidance meta-QTL overlaps that of the plant height and plant mass QTLs but not that for leaf morphology.
Equally expected is the avoidance of multiples of 3 bps overlaps for adjacent co-directional genes [ 6, 14, 15].
This may be due to common underlying mechanisms (e.g., anxiety sensitivity [ 59]) and/or symptom overlap (e.g., behavioral avoidance of feared situations is common in each anxiety disorder).
The CTV thrust level, capsule control strategy and launcher ascent trajectory constraints will be derived in order to assure the overlapping of the strategies, the avoidance of landing on Europe and the safety of the crew during the re-entry.
We find significant avoidance of disruption of Zn finger motifs only for overlap margins of between 1 and 4 residues inclusive (Table 3).
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