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Chemically modified tetracyclines have been developed to avoid unwanted effects on the endogenous microbial flora while retaining the MMP-inhibitory action.
Therefore, a careful analysis of the effects of global CRAC channel inhibition on immune responses against different types of cancer is necessary to avoid unwanted effects on cancer progression.
Because PAD4 has an important physiological role in regulating gene expression and PAD4 translocates into the nucleus from the cytosol, potential inhibitors may need to be selective for the extracellular compartment or other PAD isotypes to avoid unwanted effects on gene transcription.
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The statistical problem remains that the sample size changes with the level of species number, but taking the maximum values can avoid unwanted effects of management on maximum productivity.
Those gradients have to be consistent with the underlying lattice of the LB method in order to avoid unwanted effects of numerical anisotropy.
Site-specificity in the modification can contribute to the enhancement of useful functions and avoid unwanted effects of chemical modifications.
This outcrossing design also avoids unwanted effects of inbreeding on traits and better mimics the natural heterozygosity of low-frequency variants.
Further design of S-ketoprofen derivatives devoid of COX inhibitory activity will give opportunity to protect the kidney against oxidative attack while avoiding unwanted effects of NSAID.
Further, it has been surmised that intervening proximal to TNF (as opposed to blocking signaling farther upstream) will help avoid unwanted effects.
Potential risks The safety of nanomaterials used in food and food packaging must be fully assessed to avoid unwanted side effects.
Sophisticated methods based on electrochemical pore etching allow to produce optimized regular arrays of nanowires, which can be stabilized by intrinsic cross-links, which serve to avoid unwanted stiction effects and allow easy processing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com