Sentence examples for avoid tolerance from inspiring English sources
We tested a new schedule of injections designed to avoid tolerance and to induce neurobiological changes relevant for depression.
To avoid tolerance, separate groups of animals were tested at 24, 48, and 72 h post-PNA treatment.
However, oral delivery is challenging, requiring formulations to overcome the harsh gastrointestinal (GI) environment and avoid tolerance induction to achieve effective protection.
Thus, if this process is to be effectively manipulated in order to release the brake, we have to stimulate APCs with an antigen significantly different from "self" to recruit effector cells, balance cytokines to obtain a pro-inflammatory milieu, and finally, inhibit immune checkpoints to avoid tolerance.
Some doctors are sensitive enough to realize this, but, wanting to avoid tolerance and misuse, the responsible ones generally don't go around offering up refills out of the blue.
This titration schedule was advised in order to avoid tolerance effects.
In light of these observations, it seems important to ensure a maintained mature phenotype of the adoptively transferred CML-DC in order to avoid eventual tolerance induction.
Kratom extracts and mitragynine have been shown to possess cytotoxicity to some human cancer cell lines, namely, SH-SY5Y cells (neuronal cells), [ 34] and avoid the tolerance and dependence on chronic morphine treatment in mice as well as in human neuroblastoma SK-N-SH cell [ 35, 36].
These MPH-MR formulations provide a rapid onset of therapeutic effect, while having a sufficient duration to eliminate the need for additional doses; furthermore, they have a biphasic plasma concentration profile that avoids acute tolerance.
CD8 T cells require a third signal, along with Ag and costimulation, to make a productive response and avoid death and/or tolerance induction.
In the "edicts of pacification," which Bodin believed were the best means to avoid war, temporary tolerance takes precedence while final peace is delayed until a time when "God will grant us the grace to unite the nation in the same fold".
